In The Rocky Horror Show, The Rocky Horror Picture Show and The Rocky Horror Picture Show: Let's Do the Time Warp Again, Denton is the town where Brad Majors, Janet Weiss, Dr. Everett Von Scott, Ralph Hapschatt, and Betty Munroe live. Known as "The Home Of Happiness", it is also the location of the Denton Episcopal Church and Denton High School. The castle of Dr. Frank N Furter is located "back down the road a few miles." from Denton. In Shock Treatment, all of the action in the film takes place in a Denton TV studio. The song "Denton U.S.A.", the reality TV series "Dentonvale", and the TV network DTV, all of which appear in the film, are named after Denton.
In 1972, Richard O'Brien brought Jim Sharman his treatment for "They Came From Denton High," and together they worked it into The Rocky Horror Show. In The Rocky Horror Picture Show, Janet is reading The Plain Dealer, a Cleveland, Ohio newspaper, and the map seen in The Denton Affair (I) is that of southeastern Ohio. It has been speculated that Denton is named after Denton, Texas as The Rocky Horror Show and The Rocky Horror Picture Show share several references to the 1963 B-Movie The Yesterday Machine which takes place in Texas.